Smart wearable and implantable biosensors enable continuous, real-time monitoring of biophysical and biochemical signals for personalized and preventive healthcare. Advances in flexible, stretchable, and biocompatible materials ensure long-term comfort and seamless body integration, while multimodal and multi-analyte sensing improves robustness. AI enhances signal processing and predictive insights, yet challenges remain in motion artifacts, energy autonomy, data privacy, and clinical interpretability. This review summarizes materials, device architectures, and AI-assisted strategies applications.

Smart wearable and implantable biosensors enable continuous, real-time monitoring of biophysical and biochemical signals for personalized and preventive healthcare. Advances in flexible, stretchable, and biocompatible materials ensure long-term comfort and seamless body integration, while multimodal and multi-analyte sensing improves robustness. AI enhances signal processing and predictive insights, yet challenges remain in motion artifacts, energy autonomy, data privacy, and clinical interpretability. This review summarizes materials, device architectures, and AI-assisted strategies applications.